Fig. 2

Independent ROC curves illustrated the differentiating abilities of HMGB1, IL-6, NLRP3 and ACE2 (n = 88). Both sensitivity (Se) and specificity (Sp) values showed that classification performance of HMGB1 was better than the others. On the other hand, IL-6 and ACE2 were found to be successful in classifying COVID-19 patients with headache, while NLRP3 were found to be more successful in classifying COVID-19 patients without headache. Combined performance of these inflammatory molecules was found to be highly successful (Area under curve AUC = 0.92, Se = 0.83, Sp = 0.88)