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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

Fig. 1

Systemic deactivation of SFKs reduced cortical susceptibility to CSD and CSD-associated neuroinflammation in rat ipsilateral cortices. a Schematic presentation of cranial preparation and in vivo experimental protocol. b Representative traces of CSD affected by 1mg/kg PP2 and PP3. c d Effects of 2% DMSO, 1 mg/ml PP2 and PP3 on CSD latency and propagation rate. e f Effects of 2% DMSO, 1 mg/ml PP2 and PP3 on IL-1β and TNFα mRNA fold change after CSD in rat ipsilateral cerebral cortices. Two-tailed unpaired t-test was used for comparison in CSD latency and propagation rate between DMSO and PP2 group, PP2 and PP3 group; in IL-1β and TNFα mRNA fold change between DMSO without CSD and DMSO with CSD group, DMSO and PP2 with CSD group, PP2 and PP3 with CSD group. Significant differences were indicated by * p < 0.05, ** p < 0.01

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The Journal of Headache and Pain

ISSN: 1129-2377

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