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Table 3 Expenditure of therapeutic drugs dispensed between 2018 and 2022

From: Trends and prescribing patterns of antimigraine medicines in nine major cities in China from 2018 to 2022: a retrospective prescription analysis

 

2018

2019

2020

2021

2022

Total

P1

P2

Total therapeutic drugs

118,297.91

138,338.85

118,115.51

119,952.31

131,219.4

625,923.98

0.807

–

Analgesics

41,315.1 (34.92)

49,248.39 (35.60)

45,255.99 (38.32)

52,110.56 (43.44)

47,107.48 (35.90)

235,037.52 (37.55)

0.462

<  0.001

 NSAIDs

10,928.15 (9.24)

12,455.82 (9.00)

15,876.91 (13.44)

12,799.12 (10.67)

18,969.65 (14.46)

71,029.65 (11.35)

0.086

<  0.001

  Ibuprofen

2200.35 (1.86)

2679.09 (1.94)

2720.93 (2.30)

1446.24 (1.21)

3051.65 (2.33)

12,098.26 (1.93)

0.462

0.035

  loxoprofen

2251.35 (1.90)

2039.09 (1.47)

2834.1 (2.40)

1635.78 (1.36)

1522.87 (1.16)

10,283.19 (1.64)

0.221

<  0.001

  Celecoxib

2221.94 (1.88)

3452.58 (2.50)

5206.86 (4.41)

3096.49 (2.58)

3160.50 (2.41)

17,138.37 (2.74)

0.807

<  0.001

 Caffeine-containing agents

4202.91 (3.55)

4927.46 (3.56)

4685.18 (3.97)

5944.38 (4.96)

5793.78 (4.42)

25,553.71 (4.08)

0.462

<  0.001

 Opioids

22,237.89 (18.80)

26,689.2 (19.29)

22,059.9 (18.68)

30,866.94 (25.73)

20,883.71 (15.92)

122,737.64 (19.61)

0.462

0.987

  Codeine/Ibuprofen

13,775.59 (11.64)

15,979.8 (11.55)

11,367.54 (9.62)

14,084.68 (11.74)

12,381.48 (9.44)

67,589.09 (10.80)

0.807

<  0.001

  Dihydrocodeine/acetaminophen

1888.4 (1.60)

3458.74 (2.50)

1470.24 (1.24)

3073.32 (2.56)

2935.92 (2.24)

12,826.62 (2.05)

1.000

<  0.001

 Acetaminophen

357.25 (0.30)

530.52 (0.38)

291.16 (0.25)

225.28 (0.19)

401.30 (0.31)

1805.51 (0.29)

0.807

<  0.001

 CPMs

3588.9 (3.03)

4645.39 (3.36)

2342.84 (1.98)

2274.84 (1.90)

1059.04 (0.81)

13,911.01 (2.22)

0.086

<  0.001

Migraine-specific agents

76,982.81 (65.08)

89,090.46 (64.40)

72,859.52 (61.68)

67,841.75 (56.56)

84,111.92 (64.10)

390,886.46 (62.45)

0.807

<  0.001

 Triptans

75,457.21 (63.79)

89,090.46 (64.40)

72,859.52 (61.68)

67,841.75 (56.56)

84,111.92 (64.10)

389,360.86 (62.21)

0.807

<  0.001

  Rizatriptan

51,573.48 (43.60)

67,463.94 (48.77)

57,988.95 (49.10)

51,724.57 (43.12)

64,657.86 (49.27)

293,408.8 (46.88)

0.807

<  0.001

  zolmitriptan

22,599.21 (19.10)

21,626.52 (15.63)

14,870.57 (12.59)

16,117.18 (13.44)

19,454.06 (14.83)

94,667.54 (15.12)

0.462

<  0.001

 Ergotamine

1525.6 (1.29)

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

1525.6 (0.24)

0.289

<  0.001

Antiemetics

1187.64 (1.00)

1814.57 (1.31)

1536.61 (1.30)

954.12 (0.80)

1368.71 (1.04)

6861.65 (1.10)

0.807

<  0.001

  1. NSAIDs nonsteroidal anti-inflammatory drugs, CPMs Chinese patent medicines. P1, P value for the trend in number of prescriptions, assessed by the Mann-Kendall trend test; P2, P value for the trend in the proportion of prescriptions, assessed by the Cochran-Armitage trend test. The number of total therapeutic drugs for each year is the denominator of the data in that column
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The Journal of Headache and Pain

ISSN: 1129-2377

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