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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice

Fig. 4

EE decreased the expression of c-Fos and CGRP in the TNC. A, C. Representative fluorescent images showed a significantly decreased number of c-Fos positive cells (A) and CGRP immunoreactive fibers density (C) in the TNC of the EE + NTG mice compared to the SD + NTG mice. B, D. Quantification of c-Fos and CGRP expression. E-G. WB analysis and quantification showed that the protein expression of c-Fos (F) and CGRP (G) in the EE + NTG mice was significantly lower than that in the SD + NTG mice. The irregular white boxes show the TNC tissue. The square white boxes show higher-magnification views. Two-tailed Student’s t-test, * p < 0.05, **p < 0.01, n = 4/group, Abbreviations: TNC, trigeminal nucleus caudalis; NTG, nitroglycerin; EE, environmental enrichment; SD, standard environment

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The Journal of Headache and Pain

ISSN: 1129-2377

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