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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Provocation of attacks to discover migraine signaling mechanisms and new drug targets: early history and future perspectives - a narrative review

Fig. 2

Modified from [2]

The provocation model was fully developed using glyceryl trinitrate (GTN) infusion 0,5 µg/kg/min for 20 min. Headache is scored 0–10. There is an immediate headache during infusion, regression towards normal and then a delayed headache during which diagnostic criteria for an attack of migraine without aura are fulfilled. The lag phase between immediate and delayed headache has also been observed with other substances.

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The Journal of Headache and Pain

ISSN: 1129-2377

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