Skip to main content

Table 2 Colocalization results of 17 significant genes from blood

From: Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization

Gene

PPH0

PPH1

PPH2

PPH3

PPH4

CBFB

0.000

0.000

0.179

0.042

0.778

EP300

0.000

0.000

0.100

0.052

0.848

TGFB1

0.000

0.001

0.000

0.015

0.985

CHD4

0.000

0.000

0.057

0.055

0.888

HMGCR

0.000

0.000

0.001

0.029

0.970

TGFB3

0.000

0.000

0.055

0.000

0.945

HVCN1

0.000

0.000

0.063

0.075

0.862

THRA

0.000

0.000

0.003

0.002

0.995

NR1D1

0.000

0.000

0.003

0.002

0.995

CDK4

0.000

0.000

0.134

0.001

0.865

TLN1

0.003

0.000

0.116

0.007

0.874

TP53

0.000

0.000

0.011

0.003

0.986

PLXNB1

0.000

0.000

0.007

0.093

0.900

KCNK5

0.000

0.000

0.070

0.026

0.905

FXN

0.000

0.000

0.000

0.003

0.997

DDIT4

0.000

0.000

0.035

0.023

0.943

MRGPRE

0.000

0.000

0.000

0.008

0.992

  1. PPH0-PPH4 represent the posterior probabilities of different hypotheses, and PPH4 > 0.75 was considered as a significant colocalization result