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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury

Fig. 3

Treatment with MJN110 inhibited the expression of calcitonin gene related peptides (CGRP) in TG and TNC of mTBI mice. On day 7 post-injury, the CGRP positive immunostaining increased in the TG and TNC of mTBI mice compared to the sham group and decreased by the MJN treatment (A, C). The number of positive CGRP cells in the TG of mTBI mice was significantly higher than that in the sham group and greatly reduced by MJN (B). The same phenomenon was observed in the TNC of mTBI mice (D). *, p < 0.05, and **, p < 0.01 were obtained when the MJN treatment group compared to the TBI/vehicle group (n = 10). The mRNA levels of the calcitonin-receptor like receptor (Clr) (E) and the receptor activity modifying protein 1 (Ramp1) (F) in the TG were also increased in the TBI/vehicle group and suppressed in the MJN treatment group (n = 12/group). Scale bar = 50 μm

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The Journal of Headache and Pain

ISSN: 1129-2377

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