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Fig. 8 | The Journal of Headache and Pain

Fig. 8

From: Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury

Fig. 8

MJN110 and DO34 had opposite effects on the levels of 2-AG in TG, medulla and PAG. On day 7 post-TBI, fresh tissues from TG, medulla and PAG regions were subject to mass spectrometry to measure the 2-AG, AA and AEA contents. TBI animals treated with MJN showed highest 2-AG levels compared with the TBI/vehicle and the DO34 treatment groups in the TG, medulla and PAG regions (A). MJN and DO34 treatment significantly reduced AA in TG and medulla (B). The levels of AEA were not significantly altered in all the experimental groups (C). *, p < 0.05, **, p < 0.01, and ***, p < 0.001 (n = 10/group)

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The Journal of Headache and Pain

ISSN: 1129-2377

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