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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

Fig. 1

Design and experimental timeline of test paradigm for subcutaneous PACAP38 or saline injection in KO or WT mice. Following 1 day of habituation (day 0), five tests were done every other day over the course of 9 days. On every test day, the basal threshold of cutaneous sensitivity was measured using von Frey filaments prior to injections and the acute response was measured 1 h after PACAP38 injection. On day 9, tissues were sampled for qPCR. Carotid artery from saline treated mice were sampled between 1–4 weeks after day 9 for wire myography. Reproduced with modifications from reference [28]. Created with BioRender

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The Journal of Headache and Pain

ISSN: 1129-2377

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