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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

Fig. 3

PACAP38 induced less hypersensitivity in VPAC2 KO mice (red line) than in WT (blue line). Concurrently, PACAP38 induced migraine-relevant hypersensitivity in both WT and VPAC2 KO mice when compared to saline controls (P < 0.0001). (A) Responses one hour after subcutaneous administration of PACAP38 (2 g/kg) or saline to VPAC2 KO on five test days. (B) Descriptive representation of individual absolute data points for baseline and day 9 (acute response) with mean bars and SEMs

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