Fig. 3

PACAP38 induced less hypersensitivity in VPAC2 KO mice (red line) than in WT (blue line). Concurrently, PACAP38 induced migraine-relevant hypersensitivity in both WT and VPAC2 KO mice when compared to saline controls (P < 0.0001). (A) Responses one hour after subcutaneous administration of PACAP38 (2 g/kg) or saline to VPAC2 KO on five test days. (B) Descriptive representation of individual absolute data points for baseline and day 9 (acute response) with mean bars and SEMs