Fig. 3
Gepant plasma concentrations, pEC50 of CGRP, and interpolated CGRP-induced relaxation in the absence or presence of therapeutic gepant plasma concentrations, based on values of total Cmax (bound and unbound; A, C, E) and free fraction Cmax (corrected for plasma-protein binding; B, D, F). A-B) Maximum plasma concentration (Cmax) measured in clinical trials. C-D) pEC50 of CGRP in the absence or presence of gepants at their therapeutic plasma concentrations (Cmax). E–F) Relaxation induced by 100 nM CGRP in the presence of a therapeutic concentration of the gepants, as a percentage of the relaxation induced by 100 nM CGRP in the absence of a gepant. All data are presented as median with range