Gepant | Trial population | n | Women (%) | Age (years) | BMI (kg/m2) | Genetic background | Reference |
---|---|---|---|---|---|---|---|
Rimegepant | Lactating women | 12 | 100 | 29.8 ± 3.6a | 26.8 ± 4.9a | Race: White, 83.3% American Indian or Alaska Native, 8.3% Multiple, 8.3% Ethnicity: Hispanic or Latino, 25.0% | [6] |
 | Healthy volunteers | 6 | 50 | 41.5 ± 6.6a | 28.7 ± 1.9a | Race: White, 100% Ethnicity: Hispanic or Latino, 83.3% | [8] |
Atogepant | Healthy volunteers | 8 | 37 | 58.4 ± 3.2a (55–63)b | 28.8 ± 2.8a (24.9–32.8)b | Race: White, 87.5% Black/African American, 12.5% Ethnicity: Hispanic or Latino, 63% | [11] |
Ubrogepant | Healthy volunteers | 6 | 0 | 21–51b | 18– ≤ 32 | Race: White, 100% Ethnicity: Hispanic or Latino, 0% | [4] |
 | Healthy volunteers | 8 | 50 | 58.1 ± 2.8a (54–61)b | 28.3 ± 2.4a | Race: White, 100% Ethnicity: Hispanic or Latino, 62.5% | [12] |
Zavegepant | Healthy volunteers | 8 | NA | 18–55b | 18.5–30.0b | NA | [9] |