Skip to main content

Table 2 Demographics and clinical characteristics of the trial populations included in our analysis

From: Comparison of gepant effects at therapeutic plasma concentrations: connecting pharmacodynamics and pharmacokinetics

Gepant

Trial population

n

Women (%)

Age (years)

BMI (kg/m2)

Genetic background

Reference

Rimegepant

Lactating women

12

100

29.8 ± 3.6a

26.8 ± 4.9a

Race:

White, 83.3%

American Indian or Alaska Native, 8.3%

Multiple, 8.3%

Ethnicity:

Hispanic or Latino, 25.0%

[6]

 

Healthy volunteers

6

50

41.5 ± 6.6a

28.7 ± 1.9a

Race:

White, 100%

Ethnicity:

Hispanic or Latino, 83.3%

[8]

Atogepant

Healthy volunteers

8

37

58.4 ± 3.2a (55–63)b

28.8 ± 2.8a (24.9–32.8)b

Race:

White, 87.5%

Black/African American, 12.5%

Ethnicity:

Hispanic or Latino, 63%

[11]

Ubrogepant

Healthy volunteers

6

0

21–51b

18– ≤ 32

Race:

White, 100%

Ethnicity:

Hispanic or Latino, 0%

[4]

 

Healthy volunteers

8

50

58.1 ± 2.8a

(54–61)b

28.3 ± 2.4a

Race:

White, 100%

Ethnicity:

Hispanic or Latino, 62.5%

[12]

Zavegepant

Healthy volunteers

8

NA

18–55b

18.5–30.0b

NA

[9]

  1. NA Not available
  2. aMean ± SD
  3. brange