Fig. 2
Schematic illustration of the CMA-ROI. The CMA-ROI combines preclinical neuropharmacokinetic parameters such as Ctot, plasma, Ctot, ROI, and Kp, with in vitro equilibrium dialysis and brain slice techniques to determine drug binding properties in respective matrices (fu,plasma, fu,brain, fu,nerve) and unbound volume of distribution in the brain (Vu, brain). Created with Biorender.com