Serum microRNA qPCR profiling and validation indicate upregulation of circulating miR-145-5p and miR-26a-5p in migraineurs

Table 5 Validated target genes of miRNAs differentially expressed in migraineurs

miRNA	Target	Migraine susceptibility loci	Expressed in TG	Additional information
miR-145-5p, miR-26a-5p, miR-19a-3p	TGFBR2	×	×	TGF-β plays a role in the development of cerebral vasculature [61], some studies indicate its elevation in migraine and tension type headache [62]
miR-145-5p, miR-26a-5p, miR-19a-3p	ESR1	−	×
miR-145-5p, miR-19a-3p	ABHD17C	×	−
miR-145-5p	SNX24	×	−
miR-26a-5p	MTDH	−	×	Polymorphism of the regulatory region of MTDH (Rs1835740) found in both migraineurs and cluster headache patients [63]
	TBC1D16	×	−	Variants may predispose to moyamoya disease [64]
	PTGS2	−	×	Also known as COX2, encoding enzyme crucial to the inflammation and pain initiation and target of NSAIDs [65]
	NRP1	−	×
miR-19a-3p	NFIB	×	−
	ZBTB4	×	−
	MACF1	×	−
	CAMTA1	×	−
	RBM20	×	−

ISSN: 1129-2377