Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database

Table 1 Formulas and signal detection criterias for reporting odds ratio (ROR), proportional reporting ratio (PRR) and bayesian confidence propagation neural network (BCPNN)

Algorithms	Equation	Criteria
ROR	ROR=ad/bc	lower limitof 95%CI>1,a≥3
ROR	95%CI=eIn(ROR)±1.96(1/a+1/b+1/c+1/d)^0.5	lower limitof 95%CI>1,a≥3
PRR	PRR=a(c+d)/c/(a+b)	PRR>2,χ²>4,a>3
PRR	χ²=[(ad-bc)^2](a+b+c+d)/[(a+b)(c+d)(a+c)(b+d)]	PRR>2,χ²>4,a>3
BCPNN	IC=log₂a(a+b+c+d)(a+c)(a+b)	IC025＞0
BCPNN	95%CI=E(IC)±2V(IC)^0.5	IC025＞0
Fourfold table of disproportionality measures.	Target AE	OtherAE	Total
Target drugs	a	b	a+b
Other drugs	c	d	c + d
Total	a+c	b + d	a+b + c + d

ROR reporting odds ratio, CI confidence interval, PRR proportional reporting ratio, χ2 chi-squared, BCPNN bayesian confidence propagation neural network, IC information component, IC025 the lower limit of 95%CI, of the IC

ISSN: 1129-2377