Fig. 3

Hypothalamus-Centric Neural Circuitry Alterations in Migraine, CH, and TNP. (A) Alterations of neural projections during migraine pathophysiology. (B) Alterations of neural projections during CH pathophysiology. (C) Alterations of neural projections during TNP pathophysiology. HPTM = hypothalamus, IC = insular cortex, SSC = somatosensory cortex, TH = thalamus, AMD = amygdala, PAG = periaqueductal gray, TNC = trigeminal nucleus caudalis, CBM = cerebellum, ACC = anterior cingulate cortex, LC = locus coeruleus, SSN = Superior Salivatory Nucleus