Table 7 Results of mixed effects logistic regression model examining predictions of normal function/mildly impaired versus (severely impaired function/requires bedrest)
Variable | Odds ratio (95% CI) | p-value |
|---|---|---|
Timepoint (vs. BL [time 0]) | ||
15-min | 0.97 (0.65, 1.45) | 0.88 |
30-min | 1.31 (0.86, 2.00) | 0.21 |
45-min | 1.71 (1.10, 2.66) | 0.02 |
60-min | 2.04 (1.29, 3.23) | < 0.01 |
90-min | 1.88 (1.16, 3.03) | < 0.01 |
2-h | 1.44 (0.88, 2.38) | 0.15 |
3-h | 1.46 (0.84, 2.53) | 0.18 |
4-h | 1.28 (0.71, 2.29) | 0.41 |
6-h | 2.04 (1.01, 4.11) | 0.05 |
8-h | 2.60 (1.15, 5.90) | 0.02 |
24-h | 10.69 (2.87, 39.80) | < 0.01 |
48-h | 53.68 (3.85, 748.50) | < 0.01 |
Treatment: zav (vs. pbo at BL) | 2.96 (1.49, 5.88) | < 0.01 |
Age (scaled) (per unit increase) | 0.75 (0.56, 1.01) | 0.06 |
Sex: Male (versus female) | 1.38 (0.63, 3.01) | 0.42 |
Post-dose pain severity mod/severe (vs. none/mild) | 0.01 (0.00, 0.01) | < 0.01 |
No of attacks (scaled) (per unit increase) | 0.64 (0.47, 0.86) | < 0.01 |
Historical MBS | ||
Phonophobia (vs. nausea) | 1.56 (0.59, 4.15) | 0.37 |
Photophobia (vs. nausea) | 0.82 (0.40, 1.67) | 0.59 |
Post-dose FF photophobia: Photophobia freedom (vs. none) | 7.52 (4.47, 12.64) | < 0.01 |
Post-dose FF phonophobia: Phonophobia freedom (vs. none) | 5.50 (3.66, 8.26) | < 0.01 |
Post-dose FF nausea: Nausea freedom (vs. none) | 6.34 (4.65, 8.65) | < 0.01 |
Treatment (zav)-timepoint interaction (vs. BL) | ||
15-min | 0.62 (0.35, 1.12) | 0.11 |
30-min | 0.50 (0.27, 0.94) | 0.03 |
45-min | 0.59 (0.31, 1.14) | 0.11 |
60-min | 0.49 (0.25, 0.97) | 0.04 |
90-min | 0.49 (0.24, 0.99) | 0.05 |
2-h | 0.75 (0.36, 1.58) | 0.45 |
3-h | 0.68 (0.30, 1.51) | 0.34 |
4-h | 0.65 (0.27, 1.57) | 0.34 |
6-h | 1.05 (0.36, 3.02) | 0.93 |
8-h | 1.36 (0.39, 4.75) | 0.63 |
24-h | 0.13 (0.02, 0.92) | 0.04 |
48-h | 0.15 (0.01, 3.86) | 0.25 |