Table 3 Percentage of patients with at least one medication for study population with migraine record by preventive and acute medications
Class (N = 80,481) Medications, n(%) | Treatment indication | |
|---|---|---|
Acute | Preventive | |
NSAID n = 58,555 (72,8%) | ||
Naproxen | 42,246 (72.1) | - |
Diclofenac | 38,080 (65.0) | - |
Ibuprofen | 13,637 (23.3) | - |
Acetylsalicylic acid | 1,040 (1.8) | - |
Celecoxib | 403 (0.7) | - |
Dexketoprofen | 25 (0.04) | - |
Ketoprofen | 12 (0.02) | - |
Metamizole/Dipyrone | 3 (0.01) | - |
Corticosteroids n = 31,136 (38,7%) | ||
Dexamethasone | 30,766 (98.8) | - |
Prednisone | 646 (2.1) | - |
Triptans n = 13,446 (16.7%) | ||
Sumatriptan | 8,644 (64.3) | - |
Naratriptan | 6,691 (49.8) | - |
Zolmitriptan | 1,355 (10.1) | - |
Eleptriptan | 390 (2.9) | - |
Opioids n = 3,951 (4.9%) | ||
Tramadol | 3,719 (94.1) | - |
Dihydrocodeine/Hydrocodone | 247 (6.3) | - |
Oxycodone | 2 (0.1) | - |
Combination* n = 52,553 (65.3%) | ||
Beta-blockers n = 38,359 (47.7%) | ||
Propranolol | - | 37,865 (98.7) |
Metoprolol | - | 748 (1.9) |
Bisoprolol | - | 2 (0.005) |
Antiepileptic drugs n = 22,554 (28,0%) | ||
Topiramate | - | 11,973 (53.1) |
Valproic acid | - | 11,494Â (51.0) |
Divalproex sodium | - | 2,082 (9.2) |
Pregabalin | - | 716 (3.2) |
Gabapentin | - | 432 (1.9) |
Antidepressants n = 10,596 (13,2%) | ||
Amitriptyline | - | 9,754 (92.1) |
Venlafaxine/Desvenlafaxine | - | 920 (8.7) |
Calcium antagonist n = 6,762 (8.4%) | ||
Flunarizine | - | 6,762 (8.4) |
CGRP monoclonal antibodies n = 131 (0,2%) | ||
Galcanezumab | - | 110 (84.0) |
Erenumab | - | 29 (22.1) |
Angiotensin II receptor antagonists n = 65 (0.1%) | ||
Candesartan | - | 65 (0.1) |
Antipsychotics n = 23 (0.03%) | ||
Olanzapine | - | 23 (0.03) |
Other n = 32,563 (40.5%) | ||
Metoclopramide | 26,860 (82.5) | - |
Onabotulinum toxin A | - | 5,002 (15.4)- |
Dimenhydrinate | 3,019 (9.3) | - |
Lisinopril | - | 1 (0.003) |
Domperidone | - | 60 (0.2) |
Paracetamol | 2 (0.01) | - |