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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology

Fig. 4

A-F represent the colocalization scatter plots and Manhattan plots for the protein loci MRVI1 (discovery and replication phases), PNKP, CALCB, INPP5B, and AIF1. In each panel, the left plot compares the -log10(p) values of each single nucleotide polymorphism (SNP) for migraine risk and protein expression, with the color indicating the linkage disequilibrium (r2) with the lead SNP (purple diamond). The right plots show the genomic positions on the x-axis and the -log10(p) values for SNPs from the migraine GWAS (top) and the protein expression study (bottom) on the y-axis

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The Journal of Headache and Pain

ISSN: 1129-2377

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