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Table 3 Age of MS onset, diagnosis, and diagnostic lag in women with MS by headache status

From: Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women

 

Women with preclinical MS

Migraine + n = 43

Other headaches + n = 71

No migraine or headache (ref.) n = 146

Mean (SD)

Range

P value

Mean (SD)

Range

P value

Mean (SD)

Range

Age at MS symptom onset (years)

33.6 (5.4)

24–48

0.12

34.8 (5.7)

23–50

0.72

35.1 (5.4)

20–49

Age at MS diagnosis (years)

35.3 (5.3)

25–49

0.16

36.3 (5.8)

25–52

0.73

36.6 (5.2)

26–49

Time from MS symptom onset to diagnosis (years)

1.7 (2.0)

0–9

0.06

1.5 (2.1)

0–11

0.47

1.5 (2.1)

0–8

  1. Women with preclinical MS and I) migraine or II) other headaches were compared to a reference group of women with preclinical MS with no report of either migraine or headache. P values were calculated from t tests when normally distributed and skewed data with the Mann–Whitney U test. Range values are presented as minimum to maximum values
  2. Abbreviations: MS Multiple sclerosis, SD Standard Deviation, Preclinical MS women who developed MS after MoBa inclusion who had not yet experienced classical MS symptom onset