Fig. 2
From: Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway
TSPO was correlated to pyroptosis and inflammation in neuropathic pain. A-C GSEA results for enrichment of mitochondrial complex I assembly, enrichment of the electron transport chain and mitochondrial complex III assembly. D Venn diagram illustrating the intersection between SNI-related genes, mitochondrial genes, and differentially expressed genes (DEGs). E Schematic diagram of the experimental flow. F Von Frey results for the Sham and SNI groups at different time points (days 0, 3, 7, 14, and 21), n = 10 per group. G Western blot showing the expression levels of TSPO, NLRP3, Caspase-1, and GSDMD-N at various time points post-SNI. H–K Quantification of the relative expression of TSPO, NLRP3, Caspase-1, and GSDMD-N at various time points post-SNI, n = 10 per group. L, M ELISA results showing the levels of IL-1β and IL-18, n = 6 per group. Data are represented as mean ± SEM, ***p < 0.001