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Table 2 Characteristics of patients with clinically significant migraine by year

From: Epidemiology of clinically significant migraine in Israel: a retrospective database study

Characteristic

2017

2018

2019

2020

2021

2022

Number of patients

22 165

22 936

23 395

23 690

24 063

24 311

Sex

Female (%)

17 222 (77.7)

17 745 (77.4)

18 123 (77.5)

18 334 (77.4)

18 552 (77.1)

18 795 (77.3)

Male (%)

4941 (22.3)

5189 (22.6)

5270 (22.5)

5354 (22.6)

5509 (22.9)

5516 (22.7)

Age (mean ± SD)

44.0 ± 14.4

44.5 ± 14.6

45.1 ± 14.8

45.7 ± 14.9

46.2 ± 15.1

46.8 ± 15.2

Age category, y (%)

19–29

4171 (18.8)

4164 (18.2)

4043 (17.3)

3948 (16.7)

3816 (15.9)

3716 (15.3)

30–39

4897 (22.1)

4949 (21.6)

4968 (21.2)

4897 (20.7)

4950 (20.6)

4866 (20.0)

40–49

5194 (23.4)

5345 (23.3)

5416 (23.2)

5406 (22.8)

5363 (22.3)

5334 (21.9)

50–59

4416 (19.9)

4581 (20.0)

4677 (20.0)

4775 (20.2)

4924 (20.5)

4982 (20.5)

60–69

2592 (11.7)

2801 (12.2)

3026 (12.9)

3229 (13.6)

3375 (14.0)

3531 (14.5)

70–79

723 (3.3)

869 (3.8)

1004 (4.3)

1162 (4.9)

1334 (5.5)

1558 (6.4)

80–89

150 (0.7)

199 (0.9)

226 (1.0)

239 (1.0)

260 (1.1)

282 (1.2)

 ≥ 90

22 (0.1)

28 (0.1)

35 (0.2)

34 (0.1)

41 (0.2)

42 (0.2)

SES (%)

1–20 (mean ± SD)

9.1 ± 3.6

9.0 ± 3.6

9.0 ± 3.6

9.0 ± 3.6

8.9 ± 3.6

8.9 ± 3.6

Data not available

1306 (5.9)

1438 (6.3)

1487 (6.4)

1508 (6.4)

1641 (6.8)

1633 (6.7)

SES category (%)

0–5

3858 (18.5)

4086 (19.0)

4247 (19.4)

4365 (19.7)

4535 (20.2)

4666 (20.6)

6–8

5064 (24.3)

5156 (24.0)

5274 (24.1)

5389 (24.3)

5453 (24.3)

5549 (24.5)

9–11

6626 (31.8)

6860 (31.9)

6953 (31.7)

6992 (31.5)

7001 (31.2)

7033 (31.0)

 ≥ 12

5311 (25.5)

5396 (25.1)

5434 (24.8)

5436 (24.5)

5433 (24.2)

5430 (23.9)

Data not available

1306 (5.9)

1438 (6.3)

1487 (6.4)

1508 (6.4)

1641 (6.8)

1633 (6.7)

Region (%)

Center

6077 (27.4)

6233 (27.2)

6369 (27.2)

6445 (27.2)

6522 (27.1)

6584 (27.1)

Jerusalem

3153 (14.2)

3238 (14.1)

3365 (14.4)

3451 (14.6)

3547 (14.7)

3631 (14.9)

North

6585 (29.7)

6928 (30.2)

7045 (30.1)

7124 (30.1)

7262 (30.2)

7309 (30.1)

South

6350 (28.6)

6537 (28.5)

6616 (28.3)

6670 (28.2)

6732 (28.0)

6787 (27.9)

Ethnic category (%)

General

15 236 (68.7)

15 562 (67.9)

15 713 (67.2)

15 764 (66.5)

15 803 (65.7)

15 853 (65.2)

Arab

4770 (21.5)

5074 (22.1)

5260 (22.5)

5452 (23.0)

5712 (23.7)

5822 (24.0)

Jewish Ultra-orthodox

2159 (9.7)

2300 (10.0)

2422 (10.4)

2474 (10.4)

2548 (10.6)

2636 (10.8)

Duration of migraine diagnosis (%)

0–2

3280 (14.8)

3396 (14.8)

3059 (13.1)

2647 (11.2)

2769 (11.5)

2758 (11.3)

 ≥ 3

18 885 (85.2)

19 540 (85.2)

20 336 (86.9)

21 043 (88.8)

21 294 (88.5)

21 553 (88.7)

BMI (kg/m2) (%)

(mean ± SD)

27.0 ± 5.6

27.1 ± 5.6

27.2 ± 5.7

27.4 ± 5.7

27.4 ± 5.8

27.4 ± 5.8

Data not available

2571 (11.6)

2341 (10.2)

2078 (8.9)

2072 (8.8)

2186 (9.1)

1989 (8.2)

BMI category (%)

 < 18.5 Underweight

528 (2.7)

545 (2.7)

544 (2.6)

515 (2.4)

555 (2.5)

609 (2.7)

18.5–24.9 Normal

7226 (36.9)

7419 (36.0)

7584 (35.6)

7547 (34.9)

7589 (34.7)

7742 (34.7)

25–29.9 Overweight

6711 (34.3)

7101 (34.5)

7318 (34.3)

7447 (34.5)

7475 (34.2)

7484 (33.5)

 ≥ 30 Obese

5129 (26.2)

5530 (26.9)

5871 (27.5)

6109 (28.3)

6258 (28.6)

6487 (29.1)

Data not available

2571 (11.6)

2341 (10.2)

2078 (8.9)

2072 (8.8)

2186 (9.1)

1989 (8.2)

Migraine diagnosis by family physician during the year (%)

5548 (25.0)

5486 (23.9)

5291 (22.6)

4854 (20.5)

4803 (20.0)

4660 (19.2)

Migraine diagnosis by pain physician (%)

56 (0.3)

60 (0.3)

58 (0.3)

58 (0.2)

62 (0.3)

63 (0.3)

Criterion outpatient diagnosis by neurologist (%)

14,769 (66.6)

15 136 (66.0)

15 436 (66.0)

15 631 (66.0)

15 916 (66.1)

16 227 (66.7)

Criterion at least 2 chronic migraine diagnoses (%)

17 741 (80.0)

18 281 (79.7)

18 752 (80.2)

19 027 (80.3)

19 240 (80.0)

19 492 (80.2)

Criterion hospital diagnosis (%)

-

172 (0.8)

309 (1.3)

416 (1.8)

492 (2.0)

589 (2.4)

Criterion inpatient diagnosis (%)

-

163 (0.7)

292 (1.3)

366 (1.5)

439 (1.8)

537 (2.2)

Criterion migraine triptan use (%)

4246 (19.2)

4237 (18.5)

4151 (17.7)

3939 (16.6)

4156 (17.3)

3990 (16.4)

Criterion migraine CGRP use (%)

-

-

-

24 (0.1)

132 (0.6)

232 (1.0)

  1. CGRP calcitonin gene-related peptide, SD standard deviation, SES socioeconomic status, y year