Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

Table 1 The mediation effect of protein on cluster headache via affecting cortical thickness and surface area

Cluster headache
Protein	Cortical Thickness and Surface Area	β1	se1	β2	se2	mediation_effect	se	total_effect	p_value	Proportion
PXDNL	Supramarginal surface area	16.439	4.695	0.001	2.25 × 10^–4	0.018	0.006	−0.180	0.004	10.0%

β1 and se1 denotes the MR effect of plasma proteins on Cortical Thickness and Surface Area. β2 and se2 represents the MR effect of these Cortical Thickness and Surface Area on Cluster headache. se: standard errors of indirect effects

ISSN: 1129-2377