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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Transcutaneous occipital nerve stimulation alleviated migraine related pain by regulating synaptic plasticity and CGRP expression in the periaqueductal gray of male rats

Fig. 1

Flow chart of the experimental outline. Rats received 14 days of 10 µL IS/NS modeling (Day 0–13) followed by five-time treatments with tONS (Day 14–18). Periorbital mechanical thresholds were measured daily and video-based behavioral pain assessments were conducted on alternate days (Day 0–18). Rats were sacrificed on Day 19 for tissue harvesting. IS: inflammatory soup; NS: normal saline. tONS: transcutaneous occipital nerve stimulation. tONS parameters: True: 2/100 Hz, 4 mA, 30 min; Sham: 2/100 Hz, 0 mA, 30 min

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The Journal of Headache and Pain

ISSN: 1129-2377

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