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Table 1 Baseline characteristics of included studies

From: The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies

Author, year, location

Design

Number of endometriosis cases

Endometriosis diagnostic method

Number of controls

Migraine diagnostic method

Result

N (%) with migraine

Adjustment factors

Ferrero et al. 2004, Italy [7]

Cross-sectional

133

Laparoscopy and histology

166

Clinical by neurologist

Exposure: 51 (38.3%)

Control: 25 (15.1%)*

Migraine without aura:

Exposure: 33 (24.8%)

Control: 23 (13.9%)

Migraine with aura:

Exposure: 18 (13.5%)

Control: 2 (1.2%)

N/A

Gete et al. 2023, Australia [42]

Prospective cohort

1,149

Self-reported

6,457

Self-reported

Exposure: 682 (59%)

Control: 3,312 (51%)*

Age, residence, marital status, education, income, smoking, alcohol intake, physical activity, BMI, parity, use of hormonal therapy

Karamustafaoglu et al. 2019, Turkey [44]

Cross-sectional

114

Laparoscopy

97

Questionnaire

Exposure: 51 (69%)

Control: 26 (43%)*

N/A

Maitrot et al. 2020, France [49]

Case-control

182

Laparoscopy and histology

132

Questionnaire

Exposure: 64 (35.2%)

Control: 23 (17.4%)*

Migraine without aura:

Exposure: 55 (30.2%)

Control: 17 (12.9%)

Migraine with aura:

Exposure: 9 (4.9%)

Control: 6 (4.5%)

Age, BMI, and family history of migraine

Miller et al. 2018, USA [5]

Cross-sectional

296

Laparoscopy

95

Self-reported

Exposure: 205 (87.2%)

Control: 30 (12.8%)

Age, race, use of hormonal therapy

Mirkin et al. 2007, USA [41]

Retrospective cohort

40,150 MY

ICD codes

7,144,896 MY

ICD codes

Exposure: 8.9%

Control: 4%*

N/A

Nyholt et al. 2009, Australia [40]

Cross-sectional

767

Self-reported

164

Telephone interview

Exposure: 285 (37%)

Control: 50 (30%)

N/A

Stratton et al. 2015, USA [45]

Cross-sectional

18

Laparoscopy and histology

20

Structured interview

Exposure: 11 (61%)

Control: 0*

N/A

Sultana et al. 2024, Bangladesh [43]

Case-control

190

Laparoscopy or laparotomy

190

Clinical by neurologist

Exposure: 27 (14.2%)

Control: 5 (2.6%)*

Age, BMI

Tietjen et al. 2007, USA [46]

Cross-sectional

46

Self-report of laparoscopy

229

Clinical by neurologist

Exposure: 36 (78.3%)

Control: 127 (55.5%)

N/A

Tietjen et al. 2006, USA [4]

Case-control

16

Self-report of laparoscopy

86

Clinical by neurologist

Exposure: 14 (87.5%)

Control: 36 (41.9%)

N/A

Wu et al. 2018, Taiwan [47]

Retrospective cohort

9,191

ICD codes

27,573

ICD codes

Exposure: 398 (4.3%)

Control: 36 (41.9%)**

N/A

Wu et al. 2022, China [48]

Case-control

167

Laparoscopy

190

Clinical by neurologist

Exposure: 50 (29.9%)

Control: 23 (12.1%)*

Migraine without aura:

Exposure: 49 (29.3%)

Control: 23 (12.1%)

Migraine with aura:

Exposure: 1 (0.6%)

Control: 0

N/A

Yang et al. 2012, Taiwan [6]

Retrospective cohort

20,220

ICD codes

263,767

ICD codes

Exposure: 985 (4.9%)

Control: 7,701 (2.9%)*

Age, use of hormonal therapy

  1. N/A – not applicable; NR – not reported, OR – odds ratio; BMI – Body mass index; ICD – International Classification of Disease; MY – member years (total days of eligibility of an individual divided by 365)
  2. * p < 0.01; ** p < 0.05