Fig. 4

Proposed Mechanistic Model: Role of Vitamin A Signaling in Migraine Pathogenesis. Figure depicts how LRP1 polymorphisms, impacting LRP1 gene expression (not measured due to low blood-expression) and protein levels, may lead to migraine-related transcriptomic changes. Key processes involve retinyl-ester and retinol uptake in hepatocytes and myeloid cells. The changes ultimately result in the downregulation of CYP26B1 in a replicated allergy-uncorrected analysis, indicative of underlying physiological alterations, and other downregulated migraine-related pathways, where one example pathway each has been mentioned. Measured changes are highlighted in bold black fonts