Table 3 Genotype frequency (%) for each SNP in patients with temporomandibular disorders pain resistant (TMD-R) or successful to treatment (TMD-S), and in healthy controls
| Â | TMD-R | TMD-S | Control | p | |||
|---|---|---|---|---|---|---|---|
|  | n = 24 | n = 24 | n = 24 |  | |||
Genotype | Ancestral | Polymorphic | Ancestral | Polymorphic | Ancestral | Polymorphic | Â |
COMT rs4680 | GG | GA + AA | GG | GA + AA | GG | GA + AA |  |
n (%) | 10 (41.7) | 14 (58.3) | 12 (50.0) | 12 (50.0) | 8 (33.3) | 16 (66.7) | 0.8 |
COMT rs4818 | GG | GC + CC | GG | GC + CC | GG | GC + CC |  |
n (%) | 4 (16.7) | 20 (83.3) | 10 (41.7) | 14 (58.3) | 3 (12.5) | 21 (87.5) | 0.9 |
COMT rs4633 | CC | CT + TT | CC | CT + TT | CC | CT + TT |  |
n (%) | 10 (41.7) | 14 (58.3) | 12 (50.0) | 12 (50.0) | 8 (33.3) | 16 (66.7) | 0.8 |
HTR1 A rs6295 | GG | GC + CC | GG | GC + CC | GG | GC + CC |  |
n (%) | 2 (8.3) | 22 (91.7) | 10 (41.4) | 14 (58.3) | 11 (45.8) | 13 (54.2) | 0.02* |
HTR1B rs6296 | CC | CG + GG | CC | CG + GG | CC | CG + GG |  |
n (%) | 9 (37.5) | 15 (62.5) | 14 (58.3) | 10 (41.7) | 19 (79.2) | 5 (20.8) | 0.01# |
OPRM1 rs1799971 | AA | AG + GG | AA | AG + GG | AA | AG + GG |  |
n (%) | 18 (75) | 6 (25) | 20 (83.3) | 4 (16.7) | 16 (66.7) | 8 (33.3) | 0.8 |
SCN9 A rs6746030 | GG | GA + AA | GG | GA + AA | GG | GA + AA |  |
n (%) | 13 (54.2) | 11 (45.8) | 20 (83.3) | 4 (16.7) | 18 (75) | 6 (25) | 0.7 |