Fig. 3

Transcriptome analyses from TG, Sp5C and PAG following mTBI. a Principal component analysis of mouse transcriptome from TG, Sp5C, and PAG shows three distinct gene clusters belonging to the peripheral ganglion (TG), the medulla (Sp5C) and midbrain (PAG) regions. b Dot plots of Gene Set Enrichment Analysis (GSEA) in the TG following repetitive mTBI, representing the 15 most differentially enriched biological process gene sets obtained from the C5 collection in the mouse molecular signatures database. Dot plots of GSEA analysis in the Sp5C (c) and PAG (d) of mTBI mice, representing the most differentially enriched biological process gene sets obtained from the C5 collection in the mouse molecular signatures database. Data used for PCA and GSEA were obtained from n = 3/group/region