Fig. 7

Spatial correlation between cortical neurites alteration and nuclear imaging-derived neurotransmitter distribution. A Reduction of cortical gray matter neurites induced by Migraine vs. HC comparisons was associated with the spatial distribution of serotonin transporter and dopamine D2, dopamine transporter and 6-fluoro-(18 F)-L-3,4-dihydroxyphenylalanine neurotransmitter maps. B Reduction of cortical gray matter neurites induced by CM vs. HC comparisons was associated with the spatial distribution of dopamine D2 neurotransmitter maps. *p<0.05 (FDR correction); CM, chronic migraine; HC, healthy control; FDR, false discovery rate; 5HT1a, serotonin 5-hydroxytryptamine receptor 1a; 5HT1b, serotonin 5-hydroxytryptamine receptor 1b; 5HT2a, serotonin 5-hydroxytryptamine receptor 2a; SERT, serotonin transporter; D1, dopamine 1 receptor; D2, dopamine 2 receptor; DAT, dopamine transporter; FDOPA, 6-fluoro-(18 F)-L-3,4-dihydroxyphenylalanine; CB1, cannabinoid 1 receptor; GABAa, gamma-aminobutyricacid type a; KappaOp, Kappa Opioid Receptor; MU, µ-opioid receptor; NAT, noradrenaline transporter; NMDA, N-methyl-D-aspartic acid receptor; VAChT, vesicular acetylcholine transporter; mGluR5, metabotropic glutamate receptor 5