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  1. Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have...

    Authors: Sun Ryu, Jintao Zhang, Roli Simoes, Xuemei Liu, Zhaohua Guo, Li Feng, Jacqueline Unsinger, Richard S. Hotchkiss and Yu-Qing Cao
    Citation: The Journal of Headache and Pain 2024 25:197
    Content type: Research Published on:

  2. The gut microbiota may be involved in neuropathic pain. However, the causal association between gut microbiota and neuropathic pain remains unclear. Whether immune cells and inflammatory factors mediate the pa...

    Authors: Hao Pan, Cheng-xiao Liu, Hui-juan Zhu and Guang-fen Zhang
    Citation: The Journal of Headache and Pain 2024 25:196
    Content type: Research Published on:

  3. Patients with migraine often experience not only headache pain but also cognitive dysfunction, particularly in attention, which is frequently overlooked in both diagnosis and treatment. The influence of these ...

    Authors: Yuxin Chen, Siyuan Xie, Libo Zhang, Desheng Li, Hui Su, Rongfei Wang, Ran Ao, Xiaoxue Lin, Yingyuan Liu, Shuhua Zhang, Deqi Zhai, Yin Sun, Shuqing Wang, Li Hu, Zhao Dong and Xuejing Lu
    Citation: The Journal of Headache and Pain 2024 25:195
    Content type: Research Published on:

  4. Novel abortive treatments for migraine, ditans and gepants, have promising implications in triptan-insufficient responders with minimal existing comparative data. Our study aims to synthesize evidence through ...

    Authors: Wattakorn Laohapiboolrattana, Priabprat Jansem, Prakit Anukoolwittaya, Duangnapa Roongpiboonsopit, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Sekh Thanprasertsuk and Wanakorn Rattanawong
    Citation: The Journal of Headache and Pain 2024 25:194
    Content type: Research Published on:

  5. Calcitonin gene-related peptide (CGRP) is part of the calcitonin peptide family, which includes calcitonin (CT), amylin (AMY), and adrenomedullin (ADM). CGRP and its receptor are highly present in the trigemin...

    Authors: Aida Maddahi, Jacob C. A. Edvinsson and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2024 25:193
    Content type: Research Published on:

  6. Chronic migraine (CM) patients with medication overuse headache (MOH) were recently shown to be associated with leaky gut and inflammation. We aimed to investigate gut microbiota profiles of CM patients with M...

    Authors: Doga Vuralli, Merve Ceren Akgor, Hale Gok Dagidir, Pınar Onat, Meltem Yalinay, Ugur Sezerman and Hayrunnisa Bolay
    Citation: The Journal of Headache and Pain 2024 25:192
    Content type: Research Published on:

  7. New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. Specific abnormalities in gray matter and white matter structure are assoc...

    Authors: Di Zhang, Fangrong Zong, Yanliang Mei, Kun Zhao, Dong Qiu, Zhonghua Xiong, Xiaoshuang Li, Hefei Tang, Peng Zhang, Mantian Zhang, Yaqing Zhang, Xueying Yu, Zhe Wang, Yong Liu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:191
    Content type: Research Published on:

  8. Neck pain and primary headache disorders are highly prevalent in populations and clinical cohorts. Medication-overuse headache (MOH) is a treatable secondary headache, mainly developing in migraine sufferers, ...

    Authors: Yooha Hong, Hong-Kyun Park, Mi-Kyoung Kang, Sun-Young Oh, Jin-Ju Kang, Heui-Soo Moon, Tae-Jin Song, Mi Ji Lee, Min Kyung Chu and Soo-Jin Cho
    Citation: The Journal of Headache and Pain 2024 25:190
    Content type: Research Published on:

  9. Migraine is a common disabling conditions which, globally, affects 15.2% of the population. It is the second cause of health loss in terms of years lived with disability, the first among women. Despite being s...

    Authors: Alberto Raggi, Matilde Leonardi, Marco Arruda, Valeria Caponnetto, Matteo Castaldo, Gianluca Coppola, Adriana Della Pietra, Xiangning Fan, David Garcia-Azorin, Parisa Gazerani, Lou Grangeon, Licia Grazzi, Fu-Jung Hsiao, Keiko Ihara, Alejandro Labastida-Ramirez, Kristin Sophie Lange…
    Citation: The Journal of Headache and Pain 2024 25:189
    Content type: Review Published on:

  11. Triptans are potent 5-HT1B/1D/1F receptor agonists used in migraine therapy, thought to act through peripheral mechanisms. It remains unclear whether triptans cross the blood-brain barrier (BBB) sufficiently to s...

    Authors: Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin and Irena Loryan
    Citation: The Journal of Headache and Pain 2024 25:187
    Content type: Research Published on:

  12. Previous studies have shown that migraines are associated with brain structural changes. However, the causal relationships between these changes and migraine, as well as its subtypes, migraine with aura (MA) a...

    Authors: Zuhao Sun, Mengge Liu, Guoshu Zhao, Zhihui Zhang, Jinglei Xu, Linlin Song, Wanwan Zhang, Shaoying Wang, Linlin Jia, Qian Wu, Yue Wu, Haolin Wang, Nannan Liu, Qian Su and Feng Liu
    Citation: The Journal of Headache and Pain 2024 25:186
    Content type: Research Published on:

  13. To gain a comprehensive understanding of the altered sensory processing in patients with migraine, in this study, we developed an electroencephalography (EEG) protocol for examining brainstem and cortical resp...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yu-Te Wu, Yen-Feng Wang, Li-Ling Hope Pan, Kuan-Lin Lai, Shih-Pin Chen, Gianluca Coppola and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2024 25:185
    Content type: Research Published on:

  14. In addition to its critical role in neurogenesis, brain-derived neurotrophic factor (BDNF) modulates pain and depressive behaviors.

    Authors: Rosaria Greco, Miriam Francavilla, Sara Facchetti, Chiara Demartini, Anna Maria Zanaboni, Maria Irene Antonangeli, Mariano Maffei, Franca Cattani, Andrea Aramini, Marcello Allegretti, Cristina Tassorelli and Lidia De Filippis
    Citation: The Journal of Headache and Pain 2024 25:184
    Content type: Research Published on:

  17. Fasting-induced headaches (FIHs) have been shown to occur on the first day of Ramadan and clearly decline thereafter. Despite the wealth of knowledge about different types of headaches (e.g., migraine-, cluste...

    Authors: Abdulrahman Alwhaibi, Fawaz Alasmari, Faris Almutairi, Mohammed A. Assiri, Feras S. Aldawsari, Saud T. Aloyayd, Abdullah A. Alhejji, Jawaher A. Alotaibi, Abdulrazaq Albilali, Omar A. Almohammed and Sary Alsanea
    Citation: The Journal of Headache and Pain 2024 25:181
    Content type: Research Published on:

  18. Migraine is a common and complex neurological disorder that has a high impact on quality of life. Recent advances with drugs that target the neuropeptide calcitonin gene-related peptide (CGRP) have helped, but...

    Authors: Erik Zorrilla, Adriana Della Pietra and Andrew F. Russo
    Citation: The Journal of Headache and Pain 2024 25:178
    Content type: Review Published on:

  19. Although neuroimaging investigations have consistently demonstrated that “hyperresponsive” and “hyperconnected” visual cortices may represent the functional substrate of cortical spreading depolarization in pa...

    Authors: Marcello Silvestro, Fabrizio Esposito, Alessandro Pasquale De Rosa, Ilaria Orologio, Francesca Trojsi, Lorenzo Tartaglione, Pablo García-Polo, Gioacchino Tedeschi, Alessandro Tessitore, Mario Cirillo and Antonio Russo
    Citation: The Journal of Headache and Pain 2024 25:180
    Content type: Research Published on:

  20. Authors: Rosaria Greco, Federico Bighiani, Chiara Demartini, Annamaria Zanaboni, Miriam Francavilla, Sara Facchetti, Gloria Vaghi, Marta Allena, Daniele Martinelli, Elena Guaschino, Natascia Ghiotto, Sara Bottiroli, Michele Corrado, Francescantonio Cammarota, Alessandro Antoniazzi, Elena Mazzotta…
    Citation: The Journal of Headache and Pain 2024 25:179
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2024 25:138

  21. Although gray matter (GM) volume alterations have been extensively documented in previous voxel-based morphometry studies on vestibular migraine (VM), little is known about the impact of this disease on the to...

    Authors: Wen Chen, Hongru Zhao, Qifang Feng, Xing Xiong, Jun Ke, Lingling Dai and Chunhong Hu
    Citation: The Journal of Headache and Pain 2024 25:177
    Content type: Research Published on:

  22. Src family kinases (SFKs) contribute to migraine pathogenesis, yet its role in regulating photophobia behaviour, one of the most common forms of migraine, remains unknown. Here, we addressed whether SFKs antag...

    Authors: Zhuoan Huang, Junyu Yao, Lingdi Nie, Xinchen Nie, Xuechunhui Xiong, Sulev Kõks, John P. Quinn, Aditi Kanhere and Minyan Wang
    Citation: The Journal of Headache and Pain 2024 25:175
    Content type: Research Published on:

  23. Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of the novel CGRP receptor antagonists, the gepants, for inhibiting CGRP-induced relaxatio...

    Authors: Tessa de Vries, Dennis Schutter, Antoon van den Bogaerdt, Arnaud Vincent, Ruben Dammers, A. H. Jan Danser and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2024 25:176
    Content type: Research Published on:

  24. Recently, there has been increasing interest in the possible role of the gut microbiota (GM) in the onset of migraine. Our aim was to verify whether bacterial populations associated with intestinal dysbiosis a...

    Authors: Laura Papetti, Federica Del Chierico, Ilaria Frattale, Francesca Toto, Matteo Scanu, Stefano Levi Mortera, Federica Rapisarda, Marta Di Michele, Gabriele Monte, Fabiana Ursitti, Giorgia Sforza, Lorenza Putignani and Massimiliano Valeriani
    Citation: The Journal of Headache and Pain 2024 25:171
    Content type: Research Published on:

  25. Migraine is a prevalent neurologic disorder that affects women more than men. Examining health-related quality of life (HRQoL) by gender can aid decision makers in prioritizing future treatment and prevention ...

    Authors: Alexander C.T. Tam, Hiten Naik, Logan Trenaman, Larry Lynd and Wei Zhang
    Citation: The Journal of Headache and Pain 2024 25:170
    Content type: Research Published on:

  26. Pre-cluster symptoms (PCSs) are symptoms preceding cluster bouts and might have implications for the treatment of cluster headache (CH). This study investigated the prevalence of PCSs, and their utility in pre...

    Authors: Jr-Wei Wu, Shu-Ting Chen, Yen-Feng Wang, Shih-Pin Chen, Shin-Yi Tseng, Yih-Shiuan Kuo, Wei-Ta Chen, Chia-Chun Chiang and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2024 25:174
    Content type: Research Published on:

  28. Headache disorders, including migraine, pose a significant burden globally, with varying prevalence rates across different regions. However, research on migraine in Nigeria and other low-income countries is li...

    Authors: Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Adetola Emmanuel Babalola, Bonaventure Ukoaka, Abdulrahmon Moradeyo, Emmanuel Egbunu, Samson Afolabi, Ismaila Ajayi Yusuf and John Ehi Aboje
    Citation: The Journal of Headache and Pain 2024 25:172
    Content type: Review Published on:

  31. Migraine is a debilitating neurological disorder that presents significant management challenges, resulting in underdiagnosis and inappropriate treatments, leaving patients at risk of medication overuse (MO). ...

    Authors: Teerapong Aramruang, Akshita Malhotra, Pawin Numthavaj, Panu Looareesuwan, Thunyarat Anothaisintawee, Charungthai Dejthevaporn, Nat Sirirutbunkajorn, John Attia and Ammarin Thakkinstian
    Citation: The Journal of Headache and Pain 2024 25:165
    Content type: Review Published on:

  32. Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorl...

    Authors: Chia-Hung Wu, Pei-Lin Lee, Yen-Feng Wang, Jiing-Feng Lirng, Shu-Ting Chen, Chung-Jung Lin, Shuu-Jiun Wang, Kun-Hsien Chou and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2024 25:167
    Content type: Research Published on:

  33. Patients with migraine are vulnerable to insufficient sleep, but the impact of sleep restriction is largely unknown. In addition, the importance of sleep may be different in patients with migraine who mostly h...

    Authors: Jan Petter Neverdahl, Martin Uglem, Dagfinn Matre, Kristian Bernhard Nilsen, Knut Hagen, Gøril Bruvik Gravdahl, Trond Sand and Petter Moe Omland
    Citation: The Journal of Headache and Pain 2024 25:166
    Content type: Research Published on:

  34. Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health conditions. However, there is insufficient high-quality evidence on the association bet...

    Authors: Tsubasa Takizawa, Keiko Ihara, Miyuki Unekawa, Chisato Iba, Shizuko Kagawa, Narumi Watanabe, Shingo Nakayama, Kaori Sakurai, Naoki Miyazaki, Noriyuki Ishida, Ryo Takemura, Mamoru Shibata, Yoshikane Izawa, Shotaro Chubachi, Koichi Fukunaga and Jin Nakahara
    Citation: The Journal of Headache and Pain 2024 25:162
    Content type: Brief Report Published on:

  35. Headache disorders are among the most prevalent neurological disorders worldwide. However, whether groups differing in socioeconomic position (SEP) are disproportionately affected by headache disorders has not...

    Authors: Britta Müller, Charly Gaul, Olaf Reis, Tim P. Jürgens, Peter Kropp, Ruth Ruscheweyh, Andreas Straube, Elmar Brähler, Stefanie Förderreuther, Florian Rimmele and Thomas Dresler
    Citation: The Journal of Headache and Pain 2024 25:164
    Content type: Research Published on:

  36. Chronic migraine is closely related to the dysregulation of neurochemical substances in the brain, with metabolic imbalance being one of the proposed causes of chronic migraine. This study aims to evaluate the...

    Authors: Jinggui Gao, Da Wang, Chenlu Zhu, Jian Wang, Tianxiao Wang, Yunhao Xu, Xiao Ren, Kaibo Zhang, Cheng Peng, Jisong Guan and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:163
    Content type: Research Published on:

  37. Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30–60%. This study aimed to investigate heritability estimates in “migraine-first” ...

    Authors: Dora Torok, Peter Petschner, Daniel Baksa and Gabriella Juhasz
    Citation: The Journal of Headache and Pain 2024 25:161
    Content type: Brief Report Published on:

  38. Rimegepant, a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist, is indicated for acute and preventive migraine treatment in the United States and other countries. However, there is a l...

    Authors: Zhao Yang, Xiaodan Wang, Mengyue Niu, Qiao Wei, Huizhu Zhong, Xiaoyan Li, Weihong Yuan, Wenli Xu, Shuo Zhu, Shengyuan Yu, Jun Liu, Jianzhou Yan, Wenyan Kang and Peijian Huang
    Citation: The Journal of Headache and Pain 2024 25:160
    Content type: Research Published on:

  39. Migraine and insomnia are prevalent conditions that often co-occur, each exacerbating the other and substantially impacting the quality of life. The locus coeruleus (LC), a brainstem region responsible for nor...

    Authors: Changlin Wang, Sishi Chen, Zihan Cheng, Shiyong Xia, Chang jun Fei, Li Ye, Liang Gong, Chunhua Xi and Yu Wang
    Citation: The Journal of Headache and Pain 2024 25:159
    Content type: Research Published on:

  41. Efficacy and safety of human monoclonal antibody erenumab used for migraine prophylaxis have been shown in clinical studies. APOLLON is an open-label, multi-center, single arm study, which permits dose adjustm...

    Authors: Hartmut Göbel, Eugen Schlegel, Kathrin Jaeger, Sonja Ortler and Lea Leist
    Citation: The Journal of Headache and Pain 2024 25:157
    Content type: Research Published on:

  42. Chronic migraine is a severe and common neurological disorder, yet its precise physiological mechanisms remain unclear. The IGF1/IGF1r signaling pathway plays a crucial role in pain modulation. Studies have sh...

    Authors: Tianxiao Wang, Chenlu Zhu, Kaibo zhang, Jinggui Gao, Yunhao Xu, Chenyang Duan, Shouyi Wu, Cheng Peng, Jisong Guan and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:156
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2024 25:173

  43. New daily persistent headache (NDPH) is a continuous, unremitting headache from onset that yields suboptimal results with traditional medicines. Repetitive transcranial magnetic stimulation (rTMS) has emerged ...

    Authors: M.M. Bharath, Vimal Kumar Paliwal, Swansu Batra, Prabhakar Mishra, Naina Mishra and Romil Saini
    Citation: The Journal of Headache and Pain 2024 25:155
    Content type: Research Published on:

  44. The pathophysiology of migraine remains poorly understood, yet a growing number of studies have shown structural connectivity disruptions across large-scale brain networks. Although both structural and functio...

    Authors: Ana Matoso, Ana R. Fouto, Inês Esteves, Amparo Ruiz-Tagle, Gina Caetano, Nuno A. da Silva, Pedro Vilela, Raquel Gil-Gouveia, Rita G. Nunes and Patrícia Figueiredo
    Citation: The Journal of Headache and Pain 2024 25:154
    Content type: Research Published on:

  45. Idiopathic intracranial hypertension (IIH) is a cause of chronic headaches that are probably driven by raised intracranial pressure (ICP). Cerebral venous sinus pressure is thought to play a role in the underl...

    Authors: Federico Cagnazzo, Max Villain, Liesjet EH van Dokkum, Răzvan Alexandru Radu, Riccardo Morganti, Gregory Gascou, Cyril Dargazanli, Pierre-Henri Lefevre, Emmanuelle Le Bars, Gaetano Risi, Nicola Marchi, Anne Ducros and Vincent Costalat
    Citation: The Journal of Headache and Pain 2024 25:153
    Content type: Research Published on:

  46. Migraine is among the most prevalent and burdensome neurological disorders in the United States based on disability-adjusted life years. Cortical spreading depolarization (SD) is the most likely electrophysiol...

    Authors: Andrea M. Harriott, Melih Kaya and Cenk Ayata
    Citation: The Journal of Headache and Pain 2024 25:152
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2024 25:183

  47. Artificial intelligence (AI) is revolutionizing the field of biomedical research and treatment, leveraging machine learning (ML) and advanced algorithms to analyze extensive health and medical data more effici...

    Authors: Igor Petrušić, Woo-Seok Ha, Alejandro Labastida-Ramirez, Roberta Messina, Dilara Onan, Claudio Tana and Wei Wang
    Citation: The Journal of Headache and Pain 2024 25:151
    Content type: Review Published on:

  48. Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeas...

    Authors: Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Sekh Thanprasertsuk and Wanakorn Rattanawong
    Citation: The Journal of Headache and Pain 2024 25:150
    Content type: Brief Report Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2025 26:19

  49. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies have emerged as promising therapeutic options for the treatment of chronic migraine. However, treatment response varies considerably among indi...

    Authors: Yu-Chin An, Kuo-Sheng Hung, Chih-Sung Liang, Chia-Kuang Tsai, Chia-Lin Tsai, Sy-Jou Chen, Yu-Kai Lin, Guan-Yu Lin, Po-Kuan Yeh and Fu-Chi Yang
    Citation: The Journal of Headache and Pain 2024 25:149
    Content type: Research Published on:

  50. Migraine is a highly prevalent and complex neurovascular disease. However, the currently available therapeutic drugs often fall to adequately meet clinical needs due to limited effectiveness and numerous undes...

    Authors: Zhonghua Xiong, Lei Zhao, Yanliang Mei, Dong Qiu, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Jin Cao and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:148
    Content type: Research Published on:
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