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  1. Migraine is associated with a range of symptoms and comorbid disorders and has a strong genetic basis, but the currently identified risk loci only explain a small portion of the heritability, often termed the ...

    Authors: Fahim Faisal, Antonios Danelakis, Marte-Helene Bjørk, Bendik Winsvold, Manjit Matharu, Parashkev Nachev, Knut Hagen, Erling Tronvik and Anker Stubberud
    Citation: The Journal of Headache and Pain 2025 26:70
    Content type: Research Published on:

  2. Although the limbic system has long been thought to be involved in the pathophysiology of cluster headache, inconsistencies in imaging studies of episodic cluster headache (eCH) patients and limited understand...

    Authors: Xinyu Wang, Luhua Zhang, Yongqin Xiong, Mengmeng Hou, Shuhua Zhang, Caohui Duan, Song Wang, Xiaoyu Wang, Haoxuan Lu, Jiayu Huang, Yan Li, Zhixuan Li, Zhao Dong and Xin Lou
    Citation: The Journal of Headache and Pain 2025 26:69
    Content type: Research Published on:

  3. Pain is influenced by many factors such as personality traits and nociceptive stimuli. This study identified personality traits in patients with trigeminal neuralgia (TN) and investigated the relationships bet...

    Authors: Jeong-A Lee, Yoon Kyung Han, Won Je Jung, Byung H. Lee and Seunghoon Lee
    Citation: The Journal of Headache and Pain 2025 26:68
    Content type: Research Published on:

  4. Finding a biomarker to diagnose migraine remains a significant challenge in the headache field. Migraine patients exhibit dynamic and recurrent alterations in the brainstem-thalamo-cortical loop, including red...

    Authors: Gabriele Sebastianelli, Daniele Secci, Francesco Casillo, Chiara Abagnale, Cherubino Di Lorenzo, Mariano Serrao, Shuu-Jiun Wang, Fu-Jung Hsiao and Gianluca Coppola
    Citation: The Journal of Headache and Pain 2025 26:67
    Content type: Research Published on:

  5. Authors: Lanfranco Pellesi, David Garcia‑Azorin, Eloisa Rubio‑Beltrán, Wook‑Seok Ha, Roberta Messina, Raffaele Ornello, Igor Petrusic, Bianca Raffaelli, Alejandro Labastida‑Ramirez, Ruth Ruscheweyh, Claudio Tana, Doga Vuralli, Marta Waliszewska‑Prosół, Wei Wang and William Wells‑Gatnik
    Citation: The Journal of Headache and Pain 2025 26:66
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2024 25:214

  6. Headaches and transient neurological symptoms that bear resemblances to clinical manifestations of migraine, especially migraine with aura, are common among patients with cerebral autosomal dominant arteriopat...

    Authors: Yen-Feng Wang
    Citation: The Journal of Headache and Pain 2025 26:65
    Content type: Review Published on:

    The original article was published in The Journal of Headache and Pain 2025 26:64

  7. Migraine with aura (MA) is a hallmark feature of CADASIL, a hereditary small-vessel disease caused by NOTCH3 mutations. While MA is prevalent in CADASIL, its underlying mechanisms remain unclear, and the links...

    Authors: Hugues Chabriat
    Citation: The Journal of Headache and Pain 2025 26:64
    Content type: Review Published on:

    The Review to this article has been published in The Journal of Headache and Pain 2025 26:65

  8. Migraine is a common neurological disorder with potential pharmacological triggers. Proton pump inhibitors (PPIs), commonly prescribed for managing gastroesophageal reflux disease and other acid-related gastro...

    Authors: Prakasini Satapathy, Mahalaqua Nazli Khatib, Nasir Vadia, Soumya V. Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Muhammed Shabil, Mahendra Singh, Sanjit Sah, Doddolla Lingamaiah, Khang Wen Goh, Edward Mawejje and Ganesh Bushi
    Citation: The Journal of Headache and Pain 2025 26:63
    Content type: Review Published on:

  9. Migraine is a common neurological disorder that impacts approximately 12% of the general population and is characterized by moderate to severe headaches, nausea, mood changes, and fatigue. It impacts lower-lev...

    Authors: Keva Klamer, Joshua Craig, Christina Haines, KiAnna Sullivan, Peter Seres and Chelsea Ekstrand
    Citation: The Journal of Headache and Pain 2025 26:62
    Content type: Research Published on:

  10. Clinical observations have shown that transcutaneous occipital nerve stimulation (tONS) is effective in treating migraine. However, the underlying mechanisms are poorly understood. This study employs a rodent ...

    Authors: Yinglu Liu, Shengli Guo, Yang Li, Jingrui Mao, Xiaoxue Lin, Ruozhuo Liu, Dengfa Zhao, Zhao Dong, Shengyuan Yu and Xun Han
    Citation: The Journal of Headache and Pain 2025 26:61
    Content type: Research Published on:

  11. Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate the effects of acute sle...

    Authors: Shuqing Wang, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Deqi Zhai, Yin Sun, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou…
    Citation: The Journal of Headache and Pain 2025 26:60
    Content type: Research Published on:

  13. Migraine, a debilitating neurological disorder, is often co-occurring with sleep disturbances. This study used the Epworth Sleepiness Scale (ESS) to explore changes in sleep quality between individuals with mi...

    Authors: Arman Hajikarim-Hamedani, Setareh Rassa, Termeh Tarjoman and Mehran Shafiei
    Citation: The Journal of Headache and Pain 2025 26:58
    Content type: Research Published on:

  14. Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications o...

    Authors: Zhonghua Xiong, Zhi Guo, Lei Zhao, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Geyu Liu, Tianshuang Gao, Yonggang Wang and Xueying Yu
    Citation: The Journal of Headache and Pain 2025 26:57
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2025 26:94

  15. Continuing the series of population-based studies conducted within the Global Campaign against Headache, here we report estimates of headache-attributed burden among adults in Benin, West sub-Saharan Africa, a...

    Authors: Thierry Adoukonou, Mendinatou Agbetou, Eric Dettin, Oyéné Kossi, Andreas Husøy, Dismand Houinato and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2025 26:56
    Content type: Research Published on:

  16. Transient receptor potential melastatin 8 (TRPM8), a gene encoding a nonselective cation channel responsive to cold stimuli, has been implicated in migraine susceptibility. Despite this association, the role of T...

    Authors: Tzu-Ting Liu, Pin-Yu Chen, Chyun-Yea Tseng, Yun-Ning Chen, Jian-Bang Chen, Tz-Han Ni, Shuu-Jiun Wang, Shih-Pin Chen and Jiin-Cherng Yen
    Citation: The Journal of Headache and Pain 2025 26:55
    Content type: Research Published on:

  17. Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compared to those without MOH. However, prior studies, often limited to single imaging modalit...

    Authors: Yin Sun, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Shuqing Wang, Deqi Zhai, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou…
    Citation: The Journal of Headache and Pain 2025 26:54
    Content type: Research Published on:

  19. The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global populat...

    Authors: Jiamin Wan, Jiu Lin, Tingfeng Zha, Francisco Ciruela, Shaokang Jiang, Zuping Wu, Xinyi Fang, Qianming Chen and Xiaoyan Chen
    Citation: The Journal of Headache and Pain 2025 26:52
    Content type: Review Published on:

  20. Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce. Our study evaluated the efficacy of- and patient adherence to 675 mg fremanezumab for episodic...

    Authors: Shohei Yoshida, Noboru Imai, Masato Keicho, Jun Kamimura, Asami Moriya, Nobuyasu Yagi, Rieko Suzuki, Takashi Konishi and Masahiro Serizawa
    Citation: The Journal of Headache and Pain 2025 26:51
    Content type: Research Published on:

  21. The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus. It is considered an expression of the ...

    Authors: Giuseppe Cosentino, Elisa Antoniazzi, Camilla Cavigioli, Elena Guaschino, Natascia Ghiotto, Matteo Castaldo, Massimiliano Todisco, Roberto De Icco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2025 26:50
    Content type: Research Published on:

  23. The latest randomized controlled trial (RCT) revealed that zavegepant, a new nasal inhalation calcitonin gene-related peptide (CGRP) receptor antagonist, has a clear efficacy in the acute treatment of migraine...

    Authors: Zixiang Zhu, Yanbing Tang, Longyuan Li, Hanyu Ni, Meirong Liu, Zhouqing Chen and Zhong Wang
    Citation: The Journal of Headache and Pain 2025 26:48
    Content type: Review Published on:

  24. Vestibular migraine (VM) is a disorder characterized by recurrent episodes of dizziness or vertigo and is often accompanied by headache. The mechanisms underlying vestibular dysfunction and pain in VM remain u...

    Authors: Qingling Zhai, Qihui Chen, Ning Zhang, Hongyan Li, Qijun Yu and Yonghui Pan
    Citation: The Journal of Headache and Pain 2025 26:47
    Content type: Research Published on:

  25. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) show substantial efficacy in regulating blood glucose levels and lipid metabolism, initially as an effective treatment for diabetes mellitus. In recent year...

    Authors: Yongtao He, Biao Xu, Mengna Zhang, Dan Chen, Shuyuan Wu, Jie Gao, Yongpeng Liu, Zixin Zhang, Junzhe Kuang and Quan Fang
    Citation: The Journal of Headache and Pain 2025 26:46
    Content type: Review Published on:

  26. Migraine is a common type of primary headache which is responsible for one-third of the headache cases. It’s also considered the third highest neurological disease with disability in 2021, however, underdiagno...

    Authors: Mohamed A. Elzayat, Shorouq A. Kassab, Mona A. F. Nada and Abdel-Hady El-Gilany
    Citation: The Journal of Headache and Pain 2025 26:45
    Content type: Research Published on:

  27. Migraine is the second disabling neurological disorder with a high prevalence. Aura occurs in one-third of migraineurs and visual aura accounts for over 90%. Cortical spreading depression (CSD) underlies aura ...

    Authors: Huijuan Yuan, Weinan Na, Bozhi Li, Shuai Miao, Wenjing Tang, Li Kang, Chenghui Pi, Chunxiao Yang, Wei Xie, Tao Wang, Deqi Zhai, Dengfa Zhao, Ruozhuo Liu and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2025 26:44
    Content type: Research Published on:

  28. Medication-overuse headache (MOH) is the most common secondary headache disorder, resulting from or leading to the frequent use of acute headache medications. Despite the availability of various treatment stra...

    Authors: Prut Koonalintip, Suppakorn Yamutai, Suwanna Setthawatcharawanich, Therdpong Thongseiratch, Ply Chichareon and Benjamin R. Wakerley
    Citation: The Journal of Headache and Pain 2025 26:43
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2025 26:81

  29. Although peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly unde...

    Authors: Il-Sung Jang and Michiko Nakamura
    Citation: The Journal of Headache and Pain 2025 26:42
    Content type: Research Published on:

  30. Trigeminal neuropathic pain (TNP) is a chronic condition characterized by heightened nociceptive responses and neuroinflammatory changes. While astrocytes are recognized as critical players in pain modulation,...

    Authors: Jaisan Islam, Md Taufiqur Rahman, Muhammad Ali, Hyong Kyu Kim, Elina KC and Young Seok Park
    Citation: The Journal of Headache and Pain 2025 26:41
    Content type: Research Published on:

  31. Transient Receptor Potential Melastatin 3 (TRPM3) channels are Ca2+ permeable ion channels that act as polymodal sensors of mechanical, thermal, and various chemical stimuli. TRPM3 channels are highly expressed i...

    Authors: Georgii Krivoshein, Eduardo Rivera-Mancilla, Antoinette MaassenVanDenBrink, Rashid Giniatullin and Arn M.J.M. van den Maagdenberg
    Citation: The Journal of Headache and Pain 2025 26:40
    Content type: Review Published on:

  32. Migraine is a chronic neurological condition that has a well-documented, yet not fully understood connection to stroke, particularly in patients who experience migraine with aura (MA). Although migraine can ra...

    Authors: Michał Borończyk, Anna Zduńska, Julia Węgrzynek-Gallina, Olga Grodzka, Anetta Lasek-Bal and Izabela Domitrz
    Citation: The Journal of Headache and Pain 2025 26:39
    Content type: Review Published on:

  33. Authors: Nico Sollmann, Paul Schandelmaier, Dominik Weidlich, Jonathan Stelter, Gabby B. Joseph, Corinna Börner, Severin Schramm, Meinrad Beer, Claus Zimmer, Mirjam N. Landgraf, Florian Heinen, Dimitrios C. Karampinos, Thomas Baum and Michaela V. Bonfert
    Citation: The Journal of Headache and Pain 2025 26:38
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:84

  34. Women with migraine, especially with aura (MA), have a higher risk of white matter hyperintensities (WMH) and ischemic stroke. We aimed to assess differences in stroke etiology between women with and without m...

    Authors: Anne E. Wilms, Nelleke van der Weerd, Thijs W. van Harten, Katie M. Linstra, Hendrikus J. A. van Os, Irene de Boer, Mark C. Kruit, Antoinette Maassen van den Brink, Marieke J. H. Wermer and Gisela M. Terwindt
    Citation: The Journal of Headache and Pain 2025 26:37
    Content type: Research Published on:

  36. Deep Brain Stimulation (DBS) of the anterior cingulum has been recently proposed to treat refractory chronic pain but its safety and its efficacy have not been evaluated in controlled conditions. Our objective...

    Authors: Denys Fontaine, Aurélie Leplus, Anne Donnet, Nelly Darmon, Anne Balossier, Bruno Giordana, Benoit Simonet, Petru Isan, Jean Regis and Michel Lanteri-Minet
    Citation: The Journal of Headache and Pain 2025 26:35
    Content type: Research Published on:

  37. The relationship between physical activity (PA) and migraine is insufficiently understood. Studies have not analysed levels of PA or Time Sitting (TS) during preventive treatment, nor the role these might play...

    Authors: Álvaro Sierra-Mencía, Andrea Recio-García, David García-Azorín, Antonio José Molina de la Torre, Isabel Ros González and Ángel Luis Guerrero-Peral
    Citation: The Journal of Headache and Pain 2025 26:34
    Content type: Research Published on:

  38. Motion can exacerbate headache during a migraine attack, potentially leading to avoidance of routine physical activity. Advances in wrist-worn actigraphy facilitate objectively analyzing how headache episodes ...

    Authors: Jonas Van Der Donckt, Nicolas Vandenbussche, Mathias De Brouwer, Bram Steenwinckel, Marija Stojchevska, Femke Ongenae, Koen Paemeleire and Sofie Van Hoecke
    Citation: The Journal of Headache and Pain 2025 26:33
    Content type: Research Published on:

  39. Migraine is a complex neurological disorder with significant clinical variability, posing challenges for effective management. Multiple treatments are available for migraine, but individual responses vary wide...

    Authors: Qiuyi Chen, Jiarun Zhang, Baicheng Cao, Yihan Hu, Yazhuo Kong, Bin Li and Lu Liu
    Citation: The Journal of Headache and Pain 2025 26:32
    Content type: Review Published on:

  40. To assess the effect of modeling free water (FW) on the identification of white matter (WM) microstructure alterations using diffusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patien...

    Authors: Irene Guadilla, Ana R Fouto, Amparo Ruiz-Tagle, Inês Esteves, Gina Caetano, Nuno A Silva, Pedro Vilela, Raquel Gil-Gouveia, Santiago Aja-Fernández, Patrícia Figueiredo and Rita G Nunes
    Citation: The Journal of Headache and Pain 2025 26:31
    Content type: Research Published on:

  41. Headache conditions have a high prevalence worldwide. Office workers with high and demanding workload, but low physical activity levels are considered vulnerable for suffering from headache. This analysis exam...

    Authors: Markus J. Ernst, André Meichtry, Kerstin Luedtke and Deborah Falla
    Citation: The Journal of Headache and Pain 2025 26:30
    Content type: Research Published on:

  42. Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the enti...

    Authors: Inês Esteves, Ana R. Fouto, Amparo Ruiz-Tagle, Gina Caetano, Rita G. Nunes, Nuno A. da Silva, Pedro Vilela, Isabel Pavão Martins, Raquel Gil-Gouveia, César Caballero-Gaudes and Patrícia Figueiredo
    Citation: The Journal of Headache and Pain 2025 26:29
    Content type: Research Published on:

  44. Headache is a common neurological symptom, often leading to the investigation of secondary causes, including cerebrovascular conditions such as cranial and cervical artery dissection (CCAD). CCAD, a significan...

    Authors: Diana Doukhi, Stéphanie Debette and Jérome Mawet
    Citation: The Journal of Headache and Pain 2025 26:28
    Content type: Review Published on:

  45. Spontaneous intracranial hypotension (SIH) is a debilitating disorder, with an estimated annual incidence of 3.7 per 100,000. Diagnosing SIH can be challenging for clinicians, as patients frequently present wi...

    Authors: Linda D’Antona, Sanjay Cheema, Dwij Mehta, Fion Bremner, Laurence Dale Watkins, Ahmed Kassem Toma and Manjit Singh Matharu
    Citation: The Journal of Headache and Pain 2025 26:27
    Content type: Research Published on:

  46. Chronic migraine (CM) is a highly disabling form of migraine in which patients have ≥ 15 headache days per month, of which at least 8 have the features of migraine. Galcanezumab is a monoclonal antibody to cal...

    Authors: Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh and Holland C. Detke
    Citation: The Journal of Headache and Pain 2025 26:26
    Content type: Research Published on:

  48. Epidemiological studies on migraine are valuable for tracking disease trends, identifying risk factors, and informing treatment strategies. This study assessed the prevalence and annual incidence of clinically...

    Authors: A. Shifrin, E. Domany, M. Tirosh, D. Davidovici, S. Vinker, I. Forschner and A. Israel
    Citation: The Journal of Headache and Pain 2025 26:24
    Content type: Research Published on:

  49. Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothel...

    Authors: Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan and Moaz Elsayed Abouelmagd
    Citation: The Journal of Headache and Pain 2025 26:23
    Content type: Review Published on:

  50. Headache disorders are common, including in the working population. Clinicians caring for patients with headache need to be aware of work-related factors as potential causes or triggers of headache disorders, ...

    Authors: Xiangning Fan, Ellina Lytvyak, Charl Els and Sebastian Straube
    Citation: The Journal of Headache and Pain 2025 26:21
    Content type: Comment Published on:
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